Wile E. instantly suspects the situation, and peeks through his legs, but this only leads to him bumping his head on the ground when the Road Runner beeps.
The chase now begins in full force, ending when the Road Runner barely escapes the coyote's grip and sets a bridge on fire due to his speed.
However, the grenade, by pure misfortune, drops onto a power line and is hoisted directly back to its owner, instantly wiping the laugh off his face.
However, when he climbs out to attempt to grab his opponent, the bird points him to a looming waterfall, and Wile E. only barely steers himself back in the other direction.
Finally, the coyote tries to use raw speed to catch the Road Runner and tests his new high-speed tonic (containing "Vitamins R, P, & M") on an unsuspecting mouse.
The mouse rattles around as a "warm-up", then darts across the desert at an impossible speed, and runs up and down a rock arch to return to his tester.
Happy with this development, Wile E. releases the now-jittery mouse into his hole, and then drinks the entire bottle of it himself.
The small silo top is transformed into a rocket with Wile E. lodged in it, which is fired through the clouds with its rider and goes off, creating fireworks in the starry night sky, much to the Road Runner's amusement.