Histone H3

The term "Histone H3" alone is purposely ambiguous in that it does not distinguish between sequence variants or modification state.

Histone H3 is an important protein in the emerging field of epigenetics, where its sequence variants and variable modification states are thought to play a role in the dynamic and long term regulation of genes.

The N-terminus of H3 protrudes from the globular nucleosome core and is susceptible to post-translational modification that influence cellular processes.

These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

[5][6] Histone H3.3 has been found to play an important role in maintaining genome integrity during mammalian development.