The series stars Ally Maki, Olivia Munn, Fred Tatasciore, and Jason Sudeikis, with Nobi Nakanishi and George Takei joining for the first season, and Leslie Jones and Cristin Milioti in the second.

The series was met with generally positive reviews from critics for its animation, voice acting, action scenes, plot, and faithfulness to the source material of the comics.

co-creator Jordan Blum commented in the following year that the series has a different animation style from M.O.D.O.K..[12] In January 2022, Hulu's head of content Craig Erwich said that additional seasons of Hit-Monkey would be determined solely by the Marvel Studios team.

[3] Tatasciore, Sudeikis, Munn, and Maki return for the second season, with Leslie Jones and Cristin Milioti joining the cast.

The website's critical consensus reads: "If Marvel's Hit-Monkey is never as thrillingly original as its title might suggest, vibrant animation and a solid voice cast keep things consistently watchable.

[21] Kristen Reid of Paste stated that the animation of Hit-Monkey is remarkable with its inspiration of Japanese animation, and claimed that the level of violence and lack of morality is refreshing compared to the Marvel Cinematic Universe, while finding the sense of humor of the series entertaining despite its lack of originality.

Club gave the series a A− rating, saying that Hit-Monkey manages to be one of the best recent Marvel TV shows created, while praising the animation and the development of the villains, and complimenting the performance and chemistry of the cast.

[26] Hit-Monkey was nominated for Outstanding Color Grading - Animated Episode or Non-Theatrical Feature at the 2024 Hollywood Professional Association Awards.