Hitoyoshi Station (人吉駅, Hitoyoshi-eki) is a railway station on the Hisatsu Line and Yunomae Line in Hitoyoshi, Kumamoto, Japan, operated by Kyushu Railway Company (JR Kyushu) and Kumagawa Railroad.

The station was opened on 1 June 1908 by Japanese Government Railways (JGR) as the southern terminus of a track from Yatsushiro which was designated as the Hitoyoshi Main Line on 12 October 1909.

Through traffic was established from Mojikō in the north of Kyushu to Kagoshima in the south.

The track from Yatsushiro through Hitoyoshi to Kagoshima was thus redesignated as the Hisatsu Line on 17 October 1927.

[5] With the privatization of Japanese National Railways (JNR), the successor of JGR, on 1 April 1987, the station came under the control of JR Kyushu.