[8] Post 1962, he continued this work in the Archives of Internal Medicine and the British Postgraduate Medical Journal through to 1975, "40 consecutive Annual Reviews.

A stint as assistant physician at the Rockefeller Institute followed, working on the transformation of the pneumococcus from a rough strain to smooth and back again, under the direction of pioneering immunochemist Oswald Avery.

He spent a year at the Anton Ghon institute in Prague, as a specialist in infectious diseases, including Rocky Mountain spotted fever and tuberculous.

He then returned to the United States, where the Great Depression was manifesting, taking a position at the University of Minnesota as associate professor of medicine.

He was offered the Magee Professorship and the position of chairman of the Department of Medicine, at the Jefferson Medical College in Philadelphia.

This led to the publication of An Acute Infection of the Respiratory Tract with Atypical Pneumonia: a disease entity probably caused by a filtrable virus.

[14] In 1945, he was involved in trials of streptomycin in the Philadelphia area, and was part of the trio of doctors who reported on its potential efficacy against paratyphoid fever.

His legacy is his students and the more than 300 papers[22] he published as diagnostic achievements during the period of medical work in that preceded the age of cellular and computational study.