[1][2] Founder Wilhelm (Guillermo) Closs, who was of German descent, was born on 31 October 1841 in Baumschneis, Brazil (today's Dois Irmãos).

By a decree dated September 12, 1898, the Paraguayan government gave Closs and Reverchon a share of 16 square leagues in the then Alto Paraná, Encarnación Department.

The inhabitants are mainly focused on agriculture, specifically on the cultivation of soy, cotton, corn, manioc, yerba mate, tung, sorgo, citric, bean, peanut, and watermelon, and the stock breeding of cows, pigs and poultry.

According to the General Directorate of Statistics, Polls, and Census, the Hohenau district has the second-highest living standard in Paraguay, behind the capital, Asunción.

Among the other attractions this city offers are the German and Japanese colonies, where visitors can see unique architectural characteristics, typical foods, and cultivated fields.

Medical institutions in the city include SOS Aldea de Niños, founded August 21, 1971 on land donated by the German Association of Hohenau with 17 buildings housing 160 children; the Mother and Child Hospital; the SOS Hospital with 40 beds and 2500 monthly consultations; and the Adventist Clinic that started its medical assistance service to the district and the department in 1963.