The team takes on the case of Derrick (guest star Skylar Astin), a 19-year-old college student who had a mysterious nosebleed during cheerleading practice.
Due to his cancer giving him only five months to live, Wilson becomes resigned to his fate and does not want any further treatment, making House very angry.
He tries several methods to make Wilson change his mind, including drugging him and administering an anesthetic to render him unconscious and simulate the experience of death.
In revenge for Foreman seemingly trying to take the place of Wilson, House clogs the plumbing of a hospital toilet, causing severe flooding to the point that a ceiling collapses, injuring Adams and Park and damaging an expensive MRI machine.
As they plan a hiking trip, Foreman comes in and tells them an investigation into the flooding situation revealed that House was responsible for the damage.