On February 8, 2012, in a joint statement issued by Fox and executive producers David Shore, Katie Jacobs, and Laurie, it was revealed that the season would be the last for House.

[8] Anne Dudek, Sela Ward and Andre Braugher also reprised their previous recurring/guest roles as Amber Volakis, Stacy Warner, and Darryl Nolan, respectively.

Sarah Aldrich, Ryan Alosio, David Anders, Audrey Marie Anderson, Blake Anderson, Skylar Astin, Sharif Atkins, Mark Atteberry, Jamie Bamber, Thom Barry, E. E. Bell, Blake Bertrand, Brad Carter, Carlie Casey, George Cheung, Kevin Christy, Art Chudabala, Roma Chugami, Charles Chun, Jude Ciccolella, Enzo Cilenti, Jessie Collins, Billy Connolly, Mars M. Crain, Samantha Cutaran, Madison Davenport, Amy Davidson, Natalie Dreyfuss, Natalie Dye, Rachel Eggleston, Jamie Elman, Corri English, Arlen Escarpeta, Greg Finley, Amanda Foreman, Ralph Garman, Alexie Gilmore, Margo Harshman, Nik Isbelle, Jaclyn Jonet, Michael B. Jordan, Deborah Lacey, Lisa Lackey, Jim Lampley, James LeGros, Kai Lennix, Melanie Lynskey, Michael Massee, Heather McComb, Chris McKenna, Julie McNiven, Bridgit Mendler, Wentworth Miller, Derek Mio, Julie Mond, Nate Mooney, Ivo Nandi, Riley Lennon Nice, Michael Nouri, Michael Pare, Robert Pine, Alex Quijano, Channon Roe, Saachiko, John Scurti, Will Shadley, Brian Skala, Michael Bailey Smith, Liza Snyder, Rena Sofer, Sebastian Sozzi, Vincent Spano, Heather Stephens, Patrick Stump, Harrison Thomas, Toni Trucks, Darlene Vogel, Jake Weber, Peter Weller, David Wells, Jaleel White, Kaleti Williams, Jeffrey Wright, Jacob Zachar and Jose Zuniga.

As House scrambles to pay up, he tries to treat another inmate (Sebastian Sozzi) with joint pain while turning Dr. Jessica Adams (Odette Annable) to his point of view.

Chi Park (Charlyne Yi), a smart, young timid resident—and a new case: a set of donor lungs that are failing, threatening the life of Wilson's patient (Liza Snyder).

Final diagnosis: Eosinophilic pneumonitis When a man (Wentworth Miller) collapses after making a million dollar donation, Dr. Park believes his extreme altruism may indicate a neurological disorder, while House sees a way to fund the rebuilding of his old team back together.

Final diagnosis: Plummer's disease A CEO (Michael Nouri) begins experiencing vision problems days before a major business decision, and House sees it as the perfect way to fund the department through a little blackmail.

Meanwhile, House searches for a valid reason to attend a boxing match in Atlantic City, and Taub must decide whether to allow his ex-wife to move away, taking his daughter with her.

A man suffering from early-onset familial Alzheimer's disease (Ivo Nandi) begins vomiting, and is admitted to the hospital, with his wife (Melanie Lynskey) taking care of him.

Final diagnosis: Reye's syndrome The team takes the case of a teenage girl (Bridgit Mendler) who begins bleeding from her ear during an exam.

House and his team face a disciplinary hearing with Dr. Cofield (Jeffrey Wright) after a chemistry teacher (David Anders) is admitted to the hospital with paralysis.

Final diagnosis: Primary amoebic meningoencephalitis A boy (Riley Lennon Nice) is admitted to the hospital after nightmares about being choked led to breathing problems.

When the hospital's coroner (Jamie Elman) begins slicing his own scalp open, he is admitted but will only accept medical care personally decided on by House.

A college student (Skylar Astin) is admitted with dizziness and nosebleeds but the team soon discovers that he hears his dead brother's voice, and they must try to decide which of his symptoms are psychological in nature.

Final diagnosis: Persistent stapedial artery After failing to get out of his upcoming jail time, House disappears and his team, along with Wilson and Thirteen (Olivia Wilde), are unable to locate him.

Back at PPTH, Foreman settles into Cuddy's old job, and Chase succeeds House as director of diagnostic medicine, with Adams and Park as his new team.