[1] The soundtrack includes full length versions of songs featured in the show, such as "See the World" by Gomez, "Walter Reed" by Michael Penn, and "Teardrop", the show's opening theme, performed by Massive Attack.

It also featured songs that were recorded especially for the series that were not previously released, such as a cover of the Christina Aguilera song "Beautiful" by Elvis Costello, and covers of The Rolling Stones' "You Can't Always Get What You Want" and Cab Calloway's "Minnie The Moocher" by Band From TV.

The House, MD official television soundtrack was released on September 18, 2007 by Nettwerk Records.

[2] The CD includes two performances by Band from TV, a band formed by actor Greg Grunberg, that features television actors singing and playing instruments for charity.

[4] Chad Grischow of IGN called the soundtrack "a decent collection of too much music you probably already have on your iPod", and stated that "You will be much happier if you pick apart the pieces you are missing and grab a few songs rather than the whole album".