By 1922, the Hollandsche Bank voor Zuid-Amerika was running branches in Genoa, Hamburg, Buenos Aires, Rio de Janeiro, Santos, Santiago, São Paulo and Valparaíso.

The Hollandsche Bank voor West-Indië was established with head office in Amsterdam to operate branches in Willemstad, Curaçao.

The HBU made further acquisitions, S. van Dantzig & Co in 1939, and 's Gravenhaagsche Creditvereeniging en Depositkas in 1941.

ABN decided to merge all its activities in the Netherlands Antilles under the name Antilliaanse Bank Unie.

This meant a merger of the HBU's Netherlands Antilles branches, Aruba Commercial Bank (est.

In 2007 Fortis, which had obtained HBU in conjunction with its acquisition of ABN AMRO's operations in 2007, arranged its sale in 2009 to Deutsche Bank to comply with EU competition requirements.