The racial makeup of the CDP was 89.93% White, 5.04% Native American, 0.72% Asian, and 4.32% from two or more races.

23.6% of all households were made up of individuals, and 12.7% had someone living alone who was 65 years of age or older.

There were 6.5% of families and 9.3% of the population living below the poverty line, including 15.7% of under eighteens and none of those over 64.

Hollis has historically served as the transportation gateway for Prince of Wales Island to the regional hub of Ketchikan.

At first, it was the only community of Prince of Wales Island to receive ferry access from the Alaska Marine Highway, but in 2002, the Marine Highway ceased service to Hollis in lieu of the new Inter-Island Ferry Authority (IFA).

A few shuttle bus, taxi cab, and trucking companies provide regular service from the Hollis and Coffman Cove, Alaska ferry terminals to the other Prince of Wales island communities.