Hollis Smith (June 24, 1800 – March 29, 1863) was a businessman and political figure in Canada East, now part of the Canadian province of Quebec.
Smith was born in Plainfield, New Hampshire and grew up in Hatley Township in Lower Canada.
He helped establish Bishop's College and was a partner in the St. Lawrence and Atlantic Railroad and the Sherbrooke Cotton Factory.
In 1856, he moved his residence to Sherbrooke, where he was secretary for the Mutual Fire Insurance Company.
His daughter Susan Selina married Alexander Manning, a mayor of Toronto.