[4] She also sponsored legislation to legalize needle-exchange programs as a way to prevent the spread of hepatitis C and HIV and to encourage intravenous drug users to seek treatment.

[5] Since taking office in 2013, Rehder campaigned for legislation to establish a state database to track prescriptions for addictive drugs such as opioids.

[10][9] In supporting the proposal, Rehder cited the experience of her daughter, who had become addicted to painkillers at age 17 after receiving a prescription following a finger injury.

[14] The 27th Senate district covers a geographically large region in southeast Missouri,[3] specifically the counties of Bollinger, Cape Girardeau, Madison, Perry, Scott, and Wayne.

[15] In 2021, Rehder sponsored a measure to declare January 12 "Rush Limbaugh Day" in Missouri to commemorate the deceased conservative talk radio host.