Holmes House is a historic building in South Duffield, a village in North Yorkshire, in England.
The current building was constructed in the early 17th century as a large farmhouse, in the Artisan Mannerist style.
There were various later alterations and additions, including a substantial late-20th century range at the rear.
The middle bay projects as a two-story gabled porch containing a round-arched doorway with engaged columns, imposts, and a moulded pediment.
The outer bays contain mullioned and transomed windows in round openings with cogged surrounds.