Holmesville is a village in Holmes County, Ohio, United States, along Killbuck Creek.

Holmesville was platted in 1836, and named for its location with Holmes County.

There were 153 housing units at an average density of 665.2 per square mile (256.8/km2).

22.6% of all households were made up of individuals, and 9.5% had someone living alone who was 65 years of age or older.

There were 159 housing units at an average density of 666.2 per square mile (257.2/km2).

27.2% of all households were made up of individuals, and 12.6% had someone living alone who was 65 years of age or older.