Winesburg is an unincorporated community and census-designated place (CDP) in Paint Township, Holmes County, Ohio, in the United States.

[4] The spelling was changed to "Winesburg" by postal authorities in 1833 when a post office was opened there.

[5] Winesburg is in the southeastern part of Paint Township, in northeastern Holmes County.

According to the U.S. Census Bureau, the Winesburg CDP has a total area of 0.63 square miles (1.63 km2), of which 1.6 acres (6,533 m2), or 0.40%, are water.

U.S. Route 62, which runs through Winesburg as Main Street, leads northeast 24 miles (39 km) to downtown Canton and southwest 13 miles (21 km) to Millersburg, the Holmes county seat.