It was set up on 9 April 1945 by the Society of the Holy Child Jesus (SHCJ) and run by the Roman Catholic Archdiocese of Lagos.

It is located in South-West Ikoyi on the cusp of Obalende and Keffi; next to its brother school St Gregory's College, Lagos.

The Society founded Holy Child College, Lagos in 1945 at the invitation of Archbishop Leo Taylor, who wanted a good Catholic secondary school for the girls in his archdiocese.

The foundation students mostly came from ' Popo Aguda '(meaning Catholic Lagosians in Yoruba), who were Brazilian returnees and old Lagos families such as the Trezises, Da Rocha, Vera Cruz, Pereira, Soares and Pedro, as well as other prominent Nigerian families such as Apena, Akran, Alakija, Nwosu and Okoli.

[citation needed] Holy Child College offers an all-round academic education as well as Sports, Oratory Skills, Latin, Art and Drama, Etiquette and Deportment.