Holy Cross Catholic Secondary School is a Catholic secondary school in Strathroy, Ontario, administered by the London District Catholic School Board.

Holy Cross Catholic Secondary school opened its doors in 2002.

It was the first Catholic Secondary School in Western Middlesex County.

The school is a unique one, as it shares facilities with another school, S.D.C.I (Stratroy District Collegiate Institute), which is part of the TVDSB.

Both schools also share a complex with the town of Strathroy.