[2] The hospital was founded by the Lithuanian Roman Catholic Charities, a lay non-profit organization which entrusted the Sisters of Saint Casimir to manage it.

[2][4] Because the two non-profits had merged their resources, Sinai Health System was not required to pay any monies to acquire Holy Cross.

However, in August 2011 the transaction was cancelled, with both parties citing a downturn in the economy, as well as changes in Medicare and Medicaid, as the major factors for dissolving the partnership.

[5] The state-of-the art adult Level 1 trauma center that was to open at Holy Cross Hospital was to be a joint effort of Sinai Health System and University of Chicago Medicine.

In that way, the University of Chicago would offer an integrated program of Level 1 trauma care for both children and adults, in addition to its existing Burn and Complex Wound Center.