Holy Family Old Cathedral, located in the commercial downtown section of Anchorage, Alaska in United States of America, was the cathedral and mother church of former Roman Catholic Archdiocese of Anchorage from the erection of that archdiocese 1966 to its canonical suppression in 2020.

When Pope Francis erected the Archdiocese of Anchorage-Juneau with the combined territory of the former Archdiocese of Anchorage and the former Diocese of Juneau, canonically suppressing both former jurisdictions, in 2020, he designated Our Lady of Guadalupe Co-Cathedral as the principal cathedral and the Cathedral of the Nativity of the Blessed Virgin Mary in Juneau, Alaska, which had served as the cathedral of the Diocese of Juneau, as the co-cathedral of the new jurisdiction.

The Pope's apostolic delegate came to view the damage, and upon doing so he saw that Anchorage would be the focal point of both state and spiritual growth.

The architectural firm of McEntire and Pendergast designed a new portico of the main facade.

The cathedral was the host church for the 1981 visit of Pope John Paul II to Anchorage, which attracted a crowd estimated at 80,000 people.

In October 2014, the petition was approved and Our Lady of Guadalupe was elevated to co-cathedral status on December 14 of that year.

The Papal bull, which established the new archdiocese, designated Our Lady of Guadalupe as its cathedral and the Nativity of the Blessed Virgin Mary in Juneau as its co-cathedral.