Our Lady of Guadalupe Cathedral of the Catholic Church is located in Anchorage, Alaska, United States.

Our Lady of Guadalupe is the seat of the archbishop along with the Co-Cathedral of the Nativity of the Blessed Virgin Mary, in Juneau.

[1] The present church was designed by Architects Alaska in the Spanish Mission Revival style and completed in 2005.

[1] The cathedra installed in the church was the chair used by Pope John Paul II when he celebrated Mass in Anchorage in 1981.

In a liturgy on September 17, 2020, inaugurating the new archdiocese, the Apostolic Nuncio to the United States read the Papal bull, which designated Our Lady of Guadalupe as its cathedral and the Nativity of the Blessed Virgin Mary in Juneau as its co-cathedral.