Construction of the first church building got underway on May 31, 1871 on the site now occupied by the Elon University School of Law.

[2] In 1891, a group of parishioners split off to form St. Andrew's Episcopal Mission, which was designated a parish in 1893.

In May 1910 the two parishes consolidated to form Holy Trinity Episcopal Church.

[3] A parish house designed by Hobart Upjohn was built on the current site at Greene Street and Fisher Avenue in 1919.

Construction began on the current sanctuary in 1949, using funds raised by parishioners.