Homosassa (/ˌhoʊməˈsæsə/) is a census-designated place (CDP) in Citrus County, Florida, United States.

Homosassa is derived from a Seminole Indian name meaning either "river of fishes" or "pepper ridge".

The plantation was worked by approximately 1,000 slaves, but Yulee was an absentee owner, spending most of his time in Fernandina.

The mill, which was steam-driven, operated from 1851 to 1864 and produced sugar, syrup, and molasses, the last of which was part of the rum-making process.

After the Civil War ended in 1865, Yulee was imprisoned, the slaves were freed, and the site was abandoned.

[6] The remains of the plantation are preserved at the Yulee Sugar Mill Ruins Historic State Park.

The park has been known to have Florida panthers, black bears, red wolves, alligators and flamingos.

The Wildlife Park helps spread awareness about the dangers of boating around areas inhabited by manatees as well as the destructive effects of polluting the environment.

The CDP extends west on both sides of the Homosassa River to a network of marshes and islands that lead to the Gulf of Mexico.