Honda Toshinaga (本多 利長, 1635 – January 21, 1693) was a daimyō of the early to mid Edo period, Japan, who ruled Okazaki and Yokosuka domains, and was finally transferred to Murayama Domain in Dewa Province.

Toshinaga succeeded to clan leadership upon his father's death in 1645; however, he received only 50,000 of the 60,000 koku that had comprised Okazaki Domain under Tadatoshi's rule; the remaining 10,000 koku was divided between his brothers Honda Sukehisa and Honda Toshirō.

He held the courtesy title of junior 5th court rank, lower grade (ju go i no ge 従五位下), and Echizen no Kami and was married to a daughter of Matsudaira Masatsuna, daimyō of Tamanawa Domain in Sagami Province.

The Tokugawa shogunate confiscated Yokosuka Domain on February 23, 1682, charging Toshinaga with gross misconduct and repressive governance.

He was later pardoned, and given 10,000 koku of land in Dewa Province in northern Japan, which became known as Murayama Domain.