However, most of the present-day cities of Yokohama and Kawasaki, now part of Kanagawa Prefecture, were not in Sagami, but rather, in Musashi Province.
After the defeat of the Later Hōjō clan at the hands of Toyotomi Hideyoshi in 1590, Sagami was part of the territory in the Kantō region which came under the rule of Tokugawa Ieyasu.
With the establishment of the Tokugawa shogunate, the western portion of the province formed Odawara Domain, and the remainder of the province was tenryō territory under direct administrative control of the Tokugawa shogunate, ruled though a number of hatamoto administrators.
Uraga, at the entrance to Edo Bay was a major maritime security checkpoint for ships entering or leaving the Shogunate capital.
During the Bakumatsu period, Kurihama in southern Miura Peninsula was the location of the first landing of American Commodore Matthew C. Perry and his fleet of black ships in 1853, which led eventually to the Treaty of Kanagawa, which opened Sagami to foreign visitation and led to the rapid development of Yokohama as a treaty port.
After the Meiji Restoration, Sagami Province was reorganized in 1871 into Odarawa, Ongino-Yamanaka, Karasuyama, Mito, Sakura, Oyumi, Mutsuura and Nishi-Ohira Prefectures.