[10] Eureka Federal Savings and Loan, holder of the hotel's mortgage, foreclosed on the property and bought it at auction for $7.7 million in March 1975.

[11] In September 1975, Eureka sold the Howard Johnson's to Bernard Nemerov, a former part owner of the Riviera casino, for $10 million.

[15][16] It was later sold to Herb Pastor, owner of the Coin Castle and Golden Goose casinos in Downtown Las Vegas, who renamed the 20th Century as the Treasury Hotel.

[22] In 1989, it was purchased by Sukeaki Izumi, a Japanese industrialist and hotelier, who renovated it with an Italian Riviera ambience and renamed it the Hotel San Remo.

The company sought to take advantage of heavy development that had occurred at the nearby Tropicana – Las Vegas Boulevard intersection since 1989.

[32] Ultimately, a group of nine partners in Hooters of America acquired a two-thirds interest in the property, which was put under control of a joint venture, 155 East Tropicana, LLC.

The opening was low-key for a Las Vegas debut, with a handful of celebrities in attendance, such as TV personality Brooke Burke.

[36][41] The hotel-casino employed 1,000 workers,[42] including more than 200 of the restaurant chain's signature Hooters Girls,[43] who worked at the property as waitresses, bartenders, cocktail servers, and casino dealers.

[3] During 2007, 155 East Tropicana accepted an unsolicited offer from Hedwigs Las Vegas Top Tier, a joint venture of NTH Advisory Group and Silverleaf Real Estate, to buy the property for $225 million (including assumption of $130 million in debt).

[53] Canpartners Realty Holding Co., a subsidiary of Canyon Capital, bought up much of the company's debt at a heavy discount and planned to foreclose on the hotel.

[55][56] After a planned February 2012 auction attracted no outside bidders, the bankruptcy court approved Canpartner's $60 million credit offer for the property, with the sale expected to close around March 30.

[57] The Navegante Group was approved to manage casino operations, while Canyon Capital said it was seeking a major hotel chain to take over and rebrand the property.

[59][60] At first, Trinity was expected to rename the property and place it under the management of Holiday Inn,[61] but they later decided to retain the Hooters branding.

[62][63] Joystixx, a 21-and-over video game lounge, had opened in 2011,[64][65] but it saw minimal success and was replaced a year later by the Saloon, featuring live music.

[68][69] The world's largest Steak 'n Shake restaurant, with seating for 200 people, opened inside the Hooters casino in 2018.

[70][71] In August 2019, Oyo Hotels & Homes partnered with New York-based investment and management company Highgate to purchase the property for $135 million.

They announced plans to rename it as Oyo Hotel & Casino Las Vegas,[a] while retaining the Hooters restaurant.

[72][73] The Oyo rebranding process began on September 16, 2019,[74] and included restaurant upgrades as part of a $20 million renovation.

[76][81][82] In 1999, the show was renamed Les Trix, capitalizing on the Strip's opening of the Paris Las Vegas resort.

[77][88][89] In 1999, the San Remo debuted Night Madness, a music and magic show starring Julie McCullough and Corinna Harney.