Horace Brinsmade Silliman (December 3, 1825 – May 4, 1910) was a businessman and philanthropist from Cohoes, New York and an active layman in the Presbyterian Church.

Following graduation from Union College, Silliman became a druggist, opening a shop on Remsen Street in Cohoes.

He worked to improve the community cemetery grounds and participated in efforts to distribute relief to the poor and establish a soup kitchen.

He introduced a bill to obtain water for additional industrial power, and became Trustee of the Waterworks Sinking Fund and one of its first officials in 1870.

This Romanesque revival church stood on the corner of Mohawk and Ontario Streets for about 100 years.