Horatio first appeared in Lloyd's Register (LR) in 1800 with Bond, master, J.Bolton, owner, and trade London–Demerara.

[3] Captain Daniel Cox sailed from Liverpool on 13 October 1802 and started purchasing captives at Cape Coast Castle on 20 February 1803.

Captain John Lawson sailed from Liverpool on 17 July 1804, apparently without having acquired a letter of marque.

[6][a] In December 1804 HMS Amsterdam recaptured Horatio, of Liverpool, Lawson, master, after a French privateer had captured her.

[7] A report in Lloyd's List (LL) gave the vessel's name as Horatio, and also mentioned that the privateer had removed 160 of her people.

[8] A later report revealed that the privateer had taken out 160 of her captives, along with her crew, excepting the carpenter, boatswain, and one or two seamen.

Captain Edward Crosby sailed Horatio from Demerara on 1 April and arrived back at Liverpool on 8 June.

In his letter, Captain Ross Donnelly of Narcissus described how he had come to capture the two vessels with the assistance of the enslaving ship Columbus.

Donnelly had Columbus take "Horatio Nelson" to Cape Massarida where her late captain and part of her crew were.

[14] A later notice describes the English ship Horatio as being of 300 tons and armed with 22 guns.

On 24 October 1814, Horatio, Hannay, master, was driven ashore and damaged at Liverpool.

[20] Horatio, Hannay, master, was totally wrecked on 5 February 1817 in Dinas Dinlle, Caernarfonshire.