Horatio High School is comprehensive public junior/senior high school for seventh through twelfth grades students located in Horatio, Arkansas, United States.

The assumed course of study for students follows the Smart Core curriculum developed by the Arkansas Department of Education (ADE), which requires students complete at least 22 units to graduate.

Students engage in regular courses and exams and may take Advanced Placement (AP) coursework and exams with the opportunity for college credit.

The Horatio Lions compete in interscholastic competition in the 3A classification administered by the Arkansas Activities Association including baseball, basketball (boys/girls), football, and softball.

In the 1997 State Championship game, Horatio and Hermitage combined for 34 runs scored, an Arkansas state record.