When the hormone bind the matched receptor, it results in growth and spread of cancer cells.
[2] Breast cancer is often hormone responsive, since growth or regression of tumors can often be regulated by appropriate endocrine manipulations.
[2] Androgen deprivation therapy includes treatment with androgen receptor antagonists and/or surgical removal of the testes while estrogen deprivation therapy involves treatment with estrogen receptor antagonists and/or surgical removal of the ovaries.
In more recent years, evidence in support of this cell proliferation model of hormone responsive cancer etiology has continued to accumulate.
Anti-hormone therapies are proved to be effective in stopping progression and thereby increasing the time to recurrence or death.