The series was positively received and, despite not being shown on free-to-air terrestrial television and being criticized for its content, proved extremely popular, prompting the creation of a second season.

With a concept partly based on Songyos's 2008 film of the same name and inspired by the British series Skins, Hormones seeks to explore and portray various aspects and issues of adolescent life.

These include topics normally considered taboo for open discussion in Thai society, such as teenage sex and school violence.

[2][3] In creating the script, Songyos and the writing team conducted online research on contemporary adolescent issues, but also learned from the experiences of the young cast members.

He aimed to show the issues from a teenager's point of view and actively avoided any preaching, trying instead to have consequences of actions implied through the characters' experiences.

The story mainly takes place at the fictional Nadao Bangkok College, where the characters attend upper-secondary school.

[3] Although the series began with some uncertainty regarding its profitability, it quickly proved extremely popular, despite not being broadcast on free-to-air terrestrial television.

Hormones was widely mentioned by the press, who attributed its success to its production quality and its offering of new content lacking from usual television programming.

[32] A summons by the NBTC for the producers to discuss the show's content sparked further debate about media censorship, while supporters pointed out that some popular soap operas seen by wider audiences featured far worse behaviour.

[6] Although YouTube live streaming was still offered, the season's past episodes were now only available through the affiliated AIS Movie Store mobile application.

[33] Due to the internet and the new media, Hormones also received tremendous response from audiences outside Thailand like Vietnam, the Philippines, Indonesia and China.

In China, Hormones has a huge base of fans that watch the fan-sub version of this series in various video streaming sites.