Fon Sananthachat debuted in the entertainment industry in 2012 where she took part in the drama Muad Ohpas 2 and See Sahai Sabai Dee.

In 2014, Fon was cast in the school-horror drama, ThirTEEN Terrors along with some of the Hormones Series ensemble, in which she played as "Vee" for the first episode entitled "Wanida".

She also reprised her role as Dao for the second installment of Hormones: The Series where she developed a love line with co-actress Belle Kemisara Paladesh depicting the homosexuality and same-sex relationship issues among teenagers.

She became the main role in this series along with Baitoei Zuvapit, Meiko Chonnikan Netjui, Tou Sedthawut Anusit, Kacha Nontanun and Chatchawit Techarukpong.

Fon gained much popularity following the success of the mega hit series Hormones with her character Dao, marking her career breakthrough and rise to stardom as an actress.