On 5 September 2015, the STAR Building (Surgical, Theatres, Anesthetic, Recovery) was officially opened by NSW Minister for Health Jillian Skinner.

A new Medical Assessment Unit (MAU) has been created from the renovated remains of the old Emergency Department.

Hornsby Ku-ring-gai Hospital was featured in episodes of the TV series Sons and Daughters in 1984 when character Gordon Hamilton (portrayed by Brian Blain) was treated for a heart attack there.

It was also used frequently to film episodes of the Australian medical drama series All Saints where the historic lions outside the, soon to be demolished, "old" maternity building were featured.

Many houses in the surrounding streets, especially in Palmerston Road, have been converted to medical practices, such as ophthalmology, ear nose and throat, and other specialists.