Horse Creek is an unincorporated community and census-designated place (CDP) in Mellette County, South Dakota, United States.

U.S. Route 83 runs along the eastern edge of the CDP, leading north through White River 25 miles (40 km) to Interstate 90 at Murdo and south 20 miles (32 km) to Mission.

South Dakota Highway 44 leads east-southeast from the CDP 52 miles (84 km) to Winner.

Highway 44 follows US 83 north to White River, then turns west and leads 77 miles (124 km) to Interior, near Badlands National Park.

This South Dakota state location article is a stub.