Mission is a city on the Rosebud Indian Reservation in northern Todd County, South Dakota, United States.

The major economic center of the county, it is located at the junction of U.S. routes 18 and 83.

The city contains part of the Oyate Trail, the headquarters of the Todd County School District, Cherry-Todd Rural Electric Cooperative, and various federal/tribal agencies.

According to the United States Census Bureau, the city has a total area of 0.59 square miles (1.53 km2), all land.

[7] The closely linked communities of Antelope and White Horse, and other nearby settlements, including School District and Bureau of Indian Affairs housings and private communities, are located outside the city limits.

[citation needed] As of the census[9] of 2010, there were 1,182 people, 398 households, and 298 families living in the city.

21.4% of all households were made up of individuals, and 5.8% had someone living alone who was 65 years of age or older.