Horse Creek is a stream in Barton, Cedar, Dade and Vernon counties in southwest Missouri.
The stream headwaters arise in southern Dade County at 37°20′14″N 93°57′04″W / 37.33722°N 93.95111°W / 37.33722; -93.95111.
[1] The stream source is just east of Missouri Route 97 south of Lockwood.
It flows northwest into Barton County just east of Layneville.
Past Milford the stream turns northeast and flows into the southeast corner of Vernon County and into Cedar County northwest of West Independence.