Hosokawa Akiuji (細川 顕氏, died August 15, 1352) was a samurai general in the service of the Ashikaga Northern Court, during Japan's Nanboku-chō period.
In 1338, he was sent by Ashikaga Takauji to assist in the defence of the Kuromaru, a fortress belonging to Kanrei Shiba Takatsune.
Hosokawa fell back to Tennoji, and was defeated again, despite the aid of Yamana Tokiuji.
Though Kusunoki was defeated and killed soon afterwards, at the Battle of Shijō Nawate, Hosokawa Akiuji did not take part.
[1]: 75–76 In 1352, he helped Ashikaga Yoshiakira in pushing back Loyalist forces to Anau.