Hospital de Santa Maria MHM (European Portuguese pronunciation: [ɔʃpiˈtal dɨ ˈsɐ̃tɐ mɐˈɾi.ɐ]; "Saint Mary's Hospital") is a public Central Hospital serving the Greater Lisbon area as part of the Northern Lisbon University Hospital Centre (CHULN), a State-owned enterprise.

Santa Maria is the largest hospital in Portugal.

Saint Mary's Hospital is located in the Cidade Universitária, the main campus of the University of Lisbon and ISCTE – University Institute of Lisbon, within the civil parish of Alvalade.

Designed by German architect Hermann Distel, it was built from 1940 to 1953, meant as a new University Hospital housing the Faculty of Medicine of the University of Lisbon.

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