The manga was adapted into a twelve-episode anime television series, produced by Manglobe, and written and directed by Tomomi Mochizuki, which aired on Fuji TV's Noitamina programming block from April to July 2010.

House of Five Leaves also inspired a spin-off manga, Kozure Dōshin, serialized on the Web Ikipara Comic page of Shogakukan's Ikki Paradise website from January 2013 to June 2014.

Set during Japan's Edo period, House of Five Leaves follows Masanosuke Akitsu, a rōnin (wandering samurai) and a skilled swordsman, whose timid personality often causes him to be let go by his employers.

Written and illustrated by Natsume Ono, House of Five Leaves was serialized in Shogakukan's seinen manga magazine Monthly Ikki from November 25, 2005,[3] to July 24, 2010.

[12] A spin-off manga, Kozure Dōshin (子連れ同心, "The Constable Who Brought His Child Along"), was serialized on the Web Ikipara Comic page of Shogakukan's Ikki Paradise website from January 4, 2013, to June 6, 2014.

[34] House of Five Leaves was licensed for streaming in North America by Funimation as a part of a deal with Fuji TV allowing them to simulcast series from the Noitamina block.

[44] The American Library Association's YALSA division included House of Five Leaves on its list of Great Graphic Novels for Teens in 2011.