The gameplay in Mashiroiro Symphony follows a linear plot line, which offers pre-determined scenarios and differs upon the player's decisions, and its storyline focuses on the appeal of the four female main characters.

The gameplay in Mashiroiro Symphony requires little interaction from the player, as most of the duration of the game is only spent on reading the text that appears on the lower portion of the screen, representing either dialogue between characters, or the inner thoughts of the protagonist.

The PC-only Sana Edition contains only a single heroine's plot which is taken from the PlayStation Portable version's extended scenario and expanded further with new scenes and CGs.

Tsubasu Izumi and Burton also work on Palette's thirteenth title Koi ga Saku Koro Sakura Doki, which was released on June 27, 2014.

An all-ages edition developed by HuneX and published by Comfort playable on the PlayStation Portable (PSP), titled Mashiroiro Symphony: *mutsu no Hana, was released on June 30, 2011.

The first manga adaptation, which covers Airi Sena, was serialized between the November 2009 and October 2010 issues, published on September 26, 2009 and August 26, 2010, respectively.

[9][10] A second manga adaptation illustrated by Minazuki titled Mashiroiro Symphony: Wind of Silk (ましろ色シンフォニー -Wind of silk-), which covers Sana Inui, was serialized between the April[11] and September 2011 issues of Comp Ace.

[12] A third manga illustrated by Minazuki titled Mashiroiro Symphony: Twinkle Moon (ましろ色シンフォニー -Twinkle moon-), which covers Yutsuki Onomiya, was serialized between the October 2011 and January 2012 issues of Comp Ace.

[13] A manga anthology illustrated by various artists titled Magi-Cu 4-koma Mashiroiro Symphony was released by Enterbrain on March 25, 2010.

[15] Sakuno's CD, titled Nichiyōbi ni wa Te o Tsunaide (にちようびには手をつないで), was released on August 25, 2010.

[16] Angelina's CD, titled Tenshi ni wa Shukufuku no Mabushisa o (天使には祝福のまぶしさを), was released on September 22, 2010.

1", for the characters Airi Sena and Sakuno Uryū, sung by Ryōko Ono and Mai Gotō, respectively, was released on November 23, 2011.

2", for the characters Miu Amaha, Sana Inui and Angelina Nanatsu Sewell, sung by Noriko Rikimaru, Mayumi Yoshida and Oma Ichimura, respectively, was released on December 21, 2011.

[30] From July to September 2009, Mashiroiro Symphony ranked three times in the top ten in national PC game pre-orders in Japan.