Leonor Lasso de la Vega (b. before 1367 - d. 1432) was a Spanish noble woman from Cantabria and head of the prestigious House of Lasso de la Vega from 1367 - 1432.
She was the paternal granddaughter of Garci Lasso de la Vega II, assassinated by Peter of Castile in 1351, who was the highest royal official to the court of Fadrique Alfonso de Castilla, son of King Alfonso XI of Castile.
She was the only daughter of Garci Lasso Ruiz de la Vega, who spent his life in the service of Henry II of Castile and was killed at the Battle of Nájera in 1367 whereupon Leonor rose to the position of head of house.
The couple had the following children: When Tello died on 14 August 1385 at the Battle of Aljubarrota, Leonor remarried in 1387 with Diego Hurtado de Mendoza, High Admiral of Castile, bringing with her dowry, the title over the town of Carrión de los Condes and a manor at Asturias de Santillana.
The Cantabrian surname "Lasso de la Vega" was passed on through this maternal line at later times throughout the years and is associated with various soldiers, poets, and golden age writers such as Garcilaso de la Vega, the soldier and poet, and Inca Garcilaso, the historian from the Viceroyalty of Peru.