The church building was designed by noted New York City architect Emlen T. Littell (1838-1891), whose brother was its first rector.

The completed church was consecrated on July 14, 1863, by Bishop William Bacon Stevens.

A 1964 diocesan report described the Branchtown neighborhood as "formerly Jewish, now predominantly Negro."

In 2022, the parish reported 25 members and 14 average Sunday attendance, with $12,917 in plate and pledge financial support.

The church has had a number of internal organizations, including Scouting groups for boys and girls, Episcopal Church Women, the Brotherhood of St. Andrew for men, the Girls' Friendly Society, and the Confraternity of the Blessed Sacrament.