[13] On February 4, 2025 Rothwell announced that the series was cancelled by Hulu and described herself as "shocked, heartbroken, and frankly, baffled" by the decision.

The website's critics consensus reads, "Leveraging creator and star Natasha Rothwell's firecracker energy for a sweet and sour character study, How to Die Alone is a handy manual for relatable viewing.

[20] Aramide Tinibu of Variety described How to Die Alone as "a witty and thoughtful dramedy about loneliness, accountability, and the courage to get out of one's own way" with Natasha Rothwell delivering a "flawless" performance.

[5] Cristina Escobar of RogerEbert.com wrote that How to Die Alone offers a balance of bleak subject matter and humor, with Natasha Rothwell delivering a standout performance.

Escobar also stated that while the show has sitcom elements, it focuses on its protagonist growth beyond romance, working on her career and relationships.

She complimented the tone and called Rothwell a "fantastic leading lady," expressing hope for more seasons, especially given the need for more Black sitcoms.