Vanderslice was four months old when his parents moved to Doniphan County, in the then Kansas Territory.
After quitting school, he became a station agent at Iowa Point for the Atchison & Nebraska Railroad, which is now known as Burlington.
President Cleveland appointed Vanderslice as postmaster of White Cloud, and he served in that capacity from 1885 to 1889.
[3] In 1927 Vanderslice purchased the August R. Meyer residence and 8 acres (32,000 m2) at 44th and Warwick Boulevard adjacent to the about to be built Nelson-Atkins Museum of Art.
He donated the land to the Kansas City Art Institute and it makes up the school's main campus.