The assumed course of study follows the Smart Core curriculum developed by the Arkansas Department of Education (ADE).

Students complete regular coursework and exams and may select Advanced Placement (AP) courses and exams that may lead to college credit.

For 2012–14, the Hoxie Mustangs compete in the 3A Classification from the 3A Region 3 Conference administered by the Arkansas Activities Association.

The Mustangs participate in football, volleyball, golf (boys/girls), cheer, dance, basketball (boys/girls), baseball, softball, track (boys/girls).

[3] On March 10, 2017, the Hoxie Lady Mustangs won the Class 3A Basketball Tournament.