[1] In 1904, he was consecrated as the bishop for Stanyslaviv (now Ivano-Frankivsk) at St. George's Cathedral, taking the episcopal motto "Подъ твою милость" (Church Slavonic for "Beneath thy mercy").

[4][5] Unlike Sheptytsky, Khomyshyn believed that the UGCC should adopt a more westward orientation, further emphasizing the Uniate Church's relationship with Rome.

[6] This meant introducing Latinized practicies such as the Gregorian calendar and a strict adherence to clerical celibacy, which were met with controversy in his eparchy.

A critic of the Soviet system, having called the occupying forces "fierce beasts animated by ... the devil,"[12] he was arrested again in April 1945, and was then deported to Kyiv.

Then Dubok became outraged and grabbed some books written by the bishop, which lay on the table in front of him, and started cruelly beating His Excellency with them, on his head and everywhere else."