Huacaltzintli was a Princess of Tlatelolco and Queen of Tenochtitlan.

She was a daughter of the king Quaquapitzahuac and sister of the king Tlacateotl and queen Matlalatzin.

[1] Her husband was Itzcoatl, Aztec emperor.

She gave birth to a son, who she named Tezozomoc.

She was a grandmother of kings Axayacatl, Tizoc, and Ahuitzotl.