Huehueh Quetzalmazatzin was a tlatoani (ruler) of Amaquemecan in 15th-century Mesoamerica.
He was the son of Ipantlaqualloctzin.
His wife was Tlacocihuatzin Ilama.
Their daughter was Maquiztzin, wife of Tlacaelel and mother of Cacamatzin.
His family is mentioned by annalist Chimalpahin.