Maquiztzin was the daughter of the Chalca ruler Huehue Quetzalmacatzin and Tlacocihuatzin Ilama, in 15th-century Mesoamerica.
She married Tenochcan Tlacaelel and moved to Tenochtitlan with him.
Her eldest son was Cacamatzin.
One of other children was the great warrior Tlilpotoncatzin.
She was a grandmother of Tlacaelel II, and an ancestor of Leonor Moctezuma and María Moctezuma.