As of 2020, the comarca consists of the following municipalities: The natural comarca of Huerta de Murcia is flanked to the north and south by two mountain ranges that border the Segura River's floodplain and its tributary, the Guadalentín, locally known as El Reguerón.

The most commonly proposed administrative comarca includes the entirety of Alcantarilla, Murcia, Santomera, and Beniel.

The territory of Huerta de Murcia is further subdivided into seven sub-comarcas: The fertile valley of the Huerta de Murcia was formed by the sediments of the Quaternary era, deposited by the Segura River and the Guadalentín.

Although the Romans cultivated in the Huerta, the most significant development came with the Muslims, who drained marshlands and built an efficient irrigation system based on the Contraparada.

[3] The irrigation network of the Huerta de Murcia dates back to the Muslim era and is among the oldest in Spain.